Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

80
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
80
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

27
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
27
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

57
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
57
Nephrons01:10

Nephrons

3.4K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.4K
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

94
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
94
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

73
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
73

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Association of Markers of Kidney Tubular Secretion and Risk of Acute Kidney Injury after Acute Heart Failure.

Kidney360·2026
Same author

Erratum to Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy.

The Journal of clinical investigation·2026
Same author

Humoral Response to COVID-19 Vaccines and Infection During Sibeprenlimab Treatment of IgA Nephropathy: Data from the ENVISION Trial.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Markers of kidney tubule dysfunction and injury and long-term risk of acute kidney injury following coronary artery bypass graft surgery.

PloS one·2026
Same author

Inhibition of p65 NF-κB enhances production of galactose-deficient IgA1 through suppression of <i>C1GALT1</i> and SP1 in plasmablast-like cell subpopulations.

bioRxiv : the preprint server for biology·2026
Same author

Iptacopan in IgA Nephropathy - Final 24-Month Data.

The New England journal of medicine·2026

相关实验视频

Updated: Sep 11, 2025

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.8K

在老年人中的IgA脏病

Dana V Rizk1, Emily Dryer1,2, Ashutosh Tamhane1

  • 1Division of Nephrology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Kidney international reports
|August 15, 2025
PubMed
概括
此摘要是机器生成的。

老年患者的IgA脏病 (IgAN) 呈现严重,预后不佳. 被诊断患有Igan的老年人面临衰竭和死亡的高风险.

关键词:
在IgA脏病发作中,IgA脏病发作伊加纳伊格纳伊格纳伊格纳年长的老人老年人老年人.功能衰竭 功能衰竭是什么?死亡率 死亡率

更多相关视频

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

846
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

20.9K

相关实验视频

Last Updated: Sep 11, 2025

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.8K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

846
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

20.9K

科学领域:

  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 老年医学 老年医学
  • 免疫学 免疫学 免疫学

背景情况:

  • 关于老年患者IgA脏病 (IgAN) 的临床表现和预后的知识有限.
  • IgAN是一种常见的原发性淋巴结核炎,但它对老年人群的影响需要进一步调查.

研究的目的:

  • 评估Igan诊断时60岁或以上的患者的临床和组织学发现.
  • 在这个老年人群中检查与功能衰竭和死亡风险相关的因素.

主要方法:

  • 在1996年至2020年期间,对127名被诊断患有Igan的老年患者进行了回顾性分析.
  • 收集了临床数据,包括估计的淋巴细胞过率 (eGFR) 和蛋白尿,以及组织学MEST-C分类. 用USRDS和NDI确定功能衰竭和死亡的结果.
  • 用因特定的考克斯危险回归和标准的考克斯比例危险回归来分析功能衰竭和死亡率的预测因素.

主要成果:

  • 老年Igan患者呈现的EGFR中位数为25毫升/分钟/1.73米2,其中81%具有显著的蛋白尿.
  • 45名患者进展到功能衰竭 (平均时间为11.3年),86人死亡 (平均时间为7.5年).
  • 男性性别,诊断时的晚期CKD阶段 (3-5岁),年龄增长和晚期CKD与更高的衰竭和死亡风险有关.

结论:

  • 在老年人中诊断的IgA脏病的特点是严重的临床表型.
  • 接受Igan的老年患者预后不好,功能衰竭和过早死亡的风险很大.