双Icodextrin剂量随机对照试验的双Icodextrin剂量的老年患者在增量连续的门诊腹腔透析
Eric Goffin1, Clémence Béchade2,3,4, Cécile Courivaud5
1Department of Nephrology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
Kidney international reports
|August 15, 2025
概括
在腹膜透析 (PD) 的老年患者中,每天使用两袋伊科德克斯并没有减少对透析更改的需求,而与一袋相比. 然而,双剂量冰烯改善了超过 (UF),没有安全问题.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 透析技术 透析技术
- 临床试验 临床试验
背景情况:
- 伊科德克斯在腹腔透析 (PD) 患者中增强了超过 (UF).
- 目前的指导方针限制icodextrin的使用量为每天一袋.
研究的目的:
- 为了研究每天使用两袋伊科德克斯的优越性和安全性,而不是使用一袋.
- 为了确定双倍剂量的iCodextrin是否可以延长年龄较大的患者增量连续门诊PD (CAPD) 的持续时间.
主要方法:
- 进行了一项前性随机试验 (双Icodextrin剂量[DIDo]研究).
- 患者被随机分配到每天的双剂量 (2 个iCodextrin袋+ 1 个葡萄糖袋) 或单剂量 (1 个iCodextrin袋+ 2 个葡萄糖袋).
- 主要终点是过度使用高血压透析剂,转移到另一种透析方式或9个月后死亡的复合结果.
主要成果:
- 41名患者接受了双剂,42名患者接受了单剂.
- 在9个月和18个月的组之间,停止每天3次交换的患者比例在组之间是相似的.
- 接受双剂量伊科德克斯的患者净UF较高,使用过敏透析剂较少.
结论:
- 在增量CAPD治疗的老年患者中,双剂量伊科德克斯与单剂量相比,没有降低主要结局发生率.
- 双剂量冰凝显著增强了UF,被发现是安全的,没有发现安全问题.
相关概念视频
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
105
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
105
Peritoneal Dialysis I: Introduction and Procedure
193
Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
193
Continuous Renal Replacement Therapy
129
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
129
Peritoneal Dialysis III: Nursing Management
135
Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
135
Hemodialysis II: Procedure and Complications
126
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
126
Acute Kidney Injury V: Interprofessional Care
44
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
44


