全新纪的时间序列揭示了沉积物发育期间抗生素耐药性基因的时间动态
Hanhui Zhang1, Fu Wang2, Shenbo Yu1
1State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing 210093, China.
Environmental science & technology
|August 15, 2025
概括
抗生素耐药性基因 (ARG) 随着12000年沉积物深度的增加而自然增加,这是由微生物社区转移和移动遗传元素驱动的,而不是人类活动. 这揭示了原始环境中的自然ARG进化.
科学领域:
- 环境微生物学环境微生物学
- 基因组学就是基因组学.
- 生态系统动态生态系统动态
背景情况:
- 抗生素耐药性基因 (ARG) 动态在受人类影响的地区得到了充分研究.
- 在原始生态系统中自然ARG进化的理解很少.
- 沉积物时间序列为长期生态过程提供了一个独特的窗口.
研究的目的:
- 为了研究在12,000年前的潮间沉积物时间序列中的自然继承过程中的ARG动态.
- 确定在原始环境中ARG进化的驱动因素.
- 评估微生物群落和移动遗传元素 (MGE) 在ARG动态中的作用.
主要方法:
- 通过12,000年时间序列对沉积物的元基因组测序.
- 分析ARG的丰富性,多样性和组成变化.
- 应用中立社区模型来评估生态过程.
- 研究ARG-微生物相互作用网络和移动遗传元素 (MGE).
主要成果:
- 随着沉积物的深度和年龄,ARG的丰富性和多样性显著增加.
- ARG进化主要是由随机过程和微生物社区的改变驱动的,而不是人类活动.
- 关键的微生物族群,蛋白质细菌和活性细菌,与ARG丰富有关.
- 移动遗传元素 (MGE) 在较旧的沉积物中表现出丰富性和与ARG更密切的关联,这表明增强的水平基因转移 (HGT).
结论:
- 在原始的潮区的自然继承导致ARG的丰富性和多样性增加.
- 微生物社区的转变和移动遗传元素在ARG的独立自然进化中起着至关重要的作用.
- 这项研究为了解环境抗生素耐药性发展独立于人类影响提供了基础.
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