相关实验视频

Updated: Sep 11, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Published on: June 10, 2021

模块化单接入碳酸二甲染料作为可见光和双光子可激活光

Heng Li¹, Qian Li¹, Luying Guo¹

¹Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, School of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, China.

Journal of the American Chemical Society

|August 15, 2025

概括

研究人员开发了使用四坐标进行高效药物递送和光激活成像的新型光. 这些BODIPY-cages提供高解锁横截面和精确的药物释放,显著提高治疗疗效.

科学领域:

生物医学工程生物医学工程
有机化学有机化学
摄影化学的使用.

背景情况:

光对于药物输送和光激活成像至关重要.
提高光解量子产量和解锁光中的横截面仍然是一个挑战.

研究的目的:

开发具有高效光控制COO-B键裂解的新型光.
创建一个多样化的BODIPY-cages图书馆,用于结构-活动关系研究.
为了实现精确的光激活成像和生物系统中的药物释放.

主要方法:

使用多元组件多样性导向的一合成为BODIPY-cages.
研究了光控制的COO-B键裂变从四坐标.
对斑马鱼的光激活光成像和药物输送进行评估的光.

主要成果:

实现高解锁截面高达1488M-1厘米-1.1.
在低光剂量下证明了快速的溶酶体光激活成像.
在内分泌网膜/溶解体中展示了精确的药物释放 (酸),提高了有效性约18,540倍.
在斑马鱼中启用了连续的两光子光激活.

结论:

开发了一个多功能平台的四坐标合体光.
合成的照片提供了高解效率和双光激活功能.
这项研究为生物医学中的多功能光激活平台提供了一个新的范式.

更多相关视频

Conventional BODIPY Conjugates for Live-Cell Super-Resolution Microscopy and Single-Molecule Tracking

Conventional BODIPY Conjugates for Live-Cell Super-Resolution Microscopy and Single-Molecule Tracking

Published on: June 8, 2020

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

相关概念视频

Cycloaddition Reactions: MO Requirements for Photochemical Activation

Cycloaddition Reactions: MO Requirements for Photochemical Activation

Some cycloaddition reactions are activated by heat, while others are initiated by light. For example, a [2 + 2] cycloaddition between two ethylene molecules occurs only in the presence of light. It is photochemically allowed but thermally forbidden.

Photochemical Electrocyclic Reactions: Stereochemistry

Photochemical Electrocyclic Reactions: Stereochemistry

The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation

Cycloaddition Reactions: MO Requirements for Thermal Activation

Cycloaddition Reactions: MO Requirements for Thermal Activation

Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...