小分子降解剂结合物:评估链接器的结构-活动关系,以克服PROTAC交付中的体内障碍

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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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Published on: January 12, 2024

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Shiwei Song1, Weina Jing1, Lei Peng1

  • 1Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, China.

Journal of medicinal chemistry
|August 15, 2025
PubMed
概括

在小分子降解合物 (SMDCs) 中优化链接器化学可以改善蛋白解向仿真体 (PROTACs),用于精确的癌症治疗. 新型链接剂增强了稳定性和向性,使得较低剂量的瘤增长能够被有效地阻止.

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