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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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在白风中使用局部米诺西迪尔进行光疗:随机对照试验.

Sejal Bajoria1, Chakravarthi R Srinivas1, Nithya Satish2

  • 1Department of Dermatology, Venereology and Leprosy, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Indian dermatology online journal
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PubMed
概括

局部使用的米诺克西迪尔与光疗相结合,显著增强了白风的再颜色化. 与光疗单独相比,这种联合治疗导致白风区域和严重程度指数 (VASI) 的减少更大.

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科学领域:

  • 皮肤病学 皮肤病学
  • 照相医疗 (photomedicine) 是一种医学.
  • 皮肤病理学 皮肤病理学

背景情况:

  • 光疗是白风的主要治疗方法,通过毛囊中的黑色素细胞迁移刺激再生色素.
  • 黑色素细胞的活性,对于重新颜色化至关重要,在头发周期的异形阶段得到增强.
  • 众所周知,米诺西迪尔可以延长异原相,从而可能增加黑色素细胞可供重新颜色化.

研究的目的:

  • 评估局部用米诺克西迪尔在增强白风患者光疗诱导的再颜色化的疗效.
  • 为了比较使用米诺西迪尔加光疗与安慰剂光疗的颜色恢复率.

主要方法:

  • 一项双盲,随机对照研究,涉及30名白风患者,至少有两个受影响的斑块.
  • 一个贴片用5%局部米诺克西迪尔溶液处理,而另一个贴片用载体安慰剂治疗.
  • 两个贴片均接受光疗,在基线和4,8和12周评估白风区域和严重程度指数 (VASI).

主要成果:

  • 在12周的时间里,米诺西迪尔组的VASI得分从94 ± 9.68%显著降低到47.76 ± 17.25%.
  • 而安慰剂组的VASI得分从94±9.68%降低到67.93±16.88%,而安慰剂组的VASI得分从94±9.68%降低到67.93±16.88%.
  • 在米诺西德组,VASI的减少在统计学上更大 (P < 0.001),医生和患者的整体评估有显著差异.

结论:

  • 与光疗同时使用局部的米诺克西迪尔可显著加快白风的再生色素.
  • 组合疗法导致白风区域和严重程度指数 (VASI) 的较大减少.
  • 虽然有希望,但该研究的小样本规模和短时间的随访需要进一步调查.