超快速与标准胰岛素lispro的完全闭环控制:一个随机交叉研究模拟错过的餐 boluses
Hood Thabit1,2, Jonathan Lim1, Malgorzata E Willinska3,4
1Manchester Diabetes Centre, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
超快速胰岛素lispro (URIL) 在闭环系统中显示出更好地控制葡萄糖的趋势,即使没有饭碗. 快速起作用的胰岛素是未来自动化胰岛素输送改进的关键.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 糖尿病 技术 技术
背景情况:
- 超快速胰岛素利斯普罗 (URIL) 与标准胰岛素利斯普罗 (IL) 相比,提供更快的吸收和更早的抵消.
- 自动化胰岛素输送系统旨在改善1型糖尿病的血糖控制.
研究的目的:
- 评估URIL是否能在完全闭环系统中在8小时内改善血糖控制,与IL相比.
- 为了评估URIL在模拟错过饭的玻尿酸条件下的疗效.
主要方法:
- 一个开放的随机交叉试验,涉及18名1型糖尿病成年人接受胰岛素治疗.
- 葡萄糖水平由CamAPS FX闭环系统使用URIL或IL在两个8小时的住院治疗期间进行管理.
- 一个标准化的餐被管理没有一个餐 bolus 模拟错过的 bolusing.
主要成果:
- 在URIL (49.3%) 与IL (39.9%) 之间,时间在范围 (TIR) 在数值上更高,尽管在统计学上不显著 (p=0.072).
- 与IL相比,使用URIL的参与者在高血糖症 (1级和2级) 中的时间较短.
- 低血糖的时间很短,在两种胰岛素类型之间是可比的.
结论:
- 在没有粉囊的闭环环境中,URIL显示了改善TIR和降低高血糖的临床意义趋势.
- 进一步开发更快作用的胰岛素是必要的,以优化完全闭环系统的性能,并减少饭碗时间的负担.
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