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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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迈向下一代的可食用水凝

Gary W Liu1, Ruitao Su2, Bianca Lorraine Garcia Osterling2

  • 1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Biomacromolecules
|August 15, 2025
PubMed
概括

可吞的水凝为胃肠道提供可编程的特性. 最近可食用水凝的进步使胃肠道和全身疾病的新疗法成为可能.

科学领域:

  • 生物材料科学 生物材料科学
  • 胃肠病学 胃肠病学
  • 药物运输 药物运输 药物运输

背景情况:

  • 可吞的水凝是用于食品和治疗的聚合物材料.
  • 它们的组成允许在胃肠道内具有可编程和动态的特性.
  • 目前的应用有限,但进步提供了新的治疗潜力.

研究的目的:

  • 审查商业可食用水凝产品及其功能.
  • 讨论可摄入水凝技术的最新进展.
  • 探索可食用水凝在医学中的未来方向.

主要方法:

  • 商业上可摄入的水凝产品的审查.
  • 讨论关于先进的可食用水凝的最新科学文献.
  • 分析新兴应用,包括组织特异性活性,长时间保留和可摄入电子/机器人.

主要成果:

  • 商业上市的可食用水凝目前提供了基本的功能.
  • 最近的创新包括增强的组织特异向和超长的胃肠保留.
  • 与可摄入电子和机器人的集成是一个快速发展的领域.

结论:

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  • 先进的可食用水凝在治疗胃肠道和全身疾病方面表现有前途.
  • 临床翻译的关键考虑因素包括体内模型,监管,安全和制造.
  • 该领域有望实现显著增长,扩大治疗选择.