佩奥尼佛洛林通过调节肠道微生物群和便代谢物来改善动脉样硬化
Mengyao Xia1, Zhiping Jiang1, Bin Li2
1Pharmacy Intravenous Admixture Services, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.
mSystems
|August 15, 2025
概括
佩奥尼佛林 (PF) 通过改善脂质水平,减少炎症和恢复小鼠的肠道健康,有效地对抗动脉样硬化 (AS). 这种中国传统医学的成分通过向微生物群-代谢物轴,显示出对心血管疾病治疗的前景.
科学领域:
- 心血管科学 心血管科学
- 药理学 药理学是指药理学的学科.
- 微生物组研究 微生物组研究
背景情况:
- 动脉样硬化 (AS) 是一种与心血管疾病相关的慢性炎症性疾病.
- 作为中国传统医学的成分,佩奥尼佛林 (PF) 治疗心血管疾病的确切机制尚未完全理解.
研究的目的:
- 为了研究Paeoniflorin (PF) 在食高脂肪饮食的ApoE-/-小鼠中的抗动脉样硬化作用和潜在机制.
- 探索PF对脂质代谢,炎症,肠道微生物群和代谢途径的影响.
主要方法:
- 在使用高脂肪饮食的ApoE-/-小鼠中诱导了动脉样硬化.
- 小鼠接受了不同剂量的PF (25,50,100 mg/kg) 或阿托瓦斯塔丁治疗.
- 分析了血清脂质水平,大动脉斑块形成,TLR4和NF-κB表达,肠道微生物群组成和代谢途径.
主要成果:
- PF治疗显著降低了体重增加,血清总胆固醇,甘油三和LDL胆固醇.
- PF缓解了大动脉斑块的形成,并降低了TLR4和NF-κB的表达.
- PF改善了肠道失调,增加了有益的细菌 (乳酸菌,双菌),并调节了各种代谢途径.
结论:
- 佩奥尼佛洛林通过改善脂质样本,减少炎症和增强肠道屏障功能,显示出显著的抗动脉样硬化作用.
- PF的治疗效益与肠道微生物群和代谢障碍的调节有关,突出显示微生物群-代谢物轴.
- 这些发现支持PF作为动脉样硬化和心血管疾病治疗剂的潜力.
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