在姊妹研究队列中,久坐时间和乳腺癌风险.
Sidney M Donzella1, Molly Rogers2, Katie M O'Brien3
1University of Washington, Seattle, United States.
概括
久坐时间的增加与乳腺癌风险的增加有关,特别是在绝经后的妇女中. 然而,它在绝经前妇女中显示出保护作用,突出显示了绝经状态在这种关联中的作用.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 之前关于久坐不动行为和乳腺癌 (BC) 风险的研究已经产生了不一致的结果.
- 研究久坐时间和BC发生率之间的关系对于理解癌症病因至关重要.
研究的目的:
- 为了检查久坐时间和乳腺癌发病率之间的关联.
- 探索这种关联是如何根据更年期状态随着时间的推移而有所不同.
主要方法:
- 姐妹研究队列包括50884名年龄在35-74岁之间的女性,她们有BC的家族史.
- 通过自我报告评估和分类 (≤5,6-9,≥10小时/天) 来评估静坐时间.
- 多变量考克斯回归模型分析了BC发生率,根据共变量和更年期状态进行调整.
主要成果:
- 较长的静坐时间 (每天6-9小时和≥10小时) 与整体BC发病率的增加有关.
- 久坐时间和BC风险之间的关联因更年期状态而改变 (p-异质性=0.002).
- 在绝经前的妇女中,久坐时间与BC有反向的关联,但在绝经后的妇女中有积极的关联.
结论:
- 久坐时间的增加与乳腺癌发病率有关.
- 久坐时间和乳腺癌风险之间的关联方向取决于更年期状态.
相关概念视频
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
Longitudinal Research
12.4K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.4K
Cancer Survival Analysis
445
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
445


