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抑制USP30增强了线粒,以防止T细胞耗尽

Ruohan Zhang1, Fengxia Gao2,3, Jianying Li2,3

  • 1Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, OH, USA.

Science advances
|August 15, 2025
PubMed
概括

准USP30,它会损害CD8+ T细胞中已耗尽的线粒体功能,恢复线粒体功能并增强抗瘤免疫力. 这种方法使T细胞效应器功能复苏,为癌症免疫治疗提供了一个有前途的策略.

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