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Updated: Sep 11, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
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Published on: August 6, 2020

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与KAT7相结合的ACSS2调节了组织素β-基基化,以增强转录的作用

Siyu Wang1, Ziping Niu1, Yingao Zhang1

  • 1Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China.

Science advances
|August 15, 2025
PubMed
概括

基因组β-基布基化 (Kbhb) 将基因代谢与基因转录联系起来. 这项研究揭示了乙-CoA合成酶短链家族成员2 (ACSS2) 和氨酸乙转移酶7 (KAT7) 形成驱动这种表观遗传过程的轴.

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