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Updated: Sep 11, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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在乳腺癌中通过碳水化合物结合的PROTACs来促进GLUTs的向BRD4降解

Yunyun Gao1, Dan Ni1, Yueying Li1

  • 1Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.

Journal of medicinal chemistry
|August 15, 2025
PubMed
概括

这项研究引入了碳水化合物结合型蛋白解酶向化马体 (PROTACs),用于向癌症治疗. 新型化合物NG-2有效降解GLUTs过度表达细胞中的癌症蛋白质,显示毒性降低并抑制瘤生长.

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