爱斯坦-巴尔病毒 (EBV) 感染及其后果在免疫能力强的宿主中
Madeline R Meirhaeghe1, Henry H Balfour2
1Department of Laboratory Medicine and Pathology, University of Minnesota, University of Minnesota Medical School, Minneapolis, MN 55455, United States.
概括
爱斯坦-巴尔病毒 (EBV) 引起传染性单核病,但可能导致严重的长期健康问题. 本综述研究了EBV在癌症和自身免疫性疾病 (如多发性硬化症) 中的作用.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 神经学 神经学
背景情况:
- 爱斯坦-巴尔病毒 (EBV) 是一种常见的人类疹病毒.
- 初级EBV感染通常表现为传染性单核病.
- 长期EBV感染的健康后果是显著的.
研究的目的:
- 在免疫能力强的个体中审查爱斯坦-巴尔病毒感染的后果.
- 突出EBV与单核病以外的各种疾病之间的联系.
主要方法:
- 关于爱斯坦-巴尔病毒研究的文献综述.
- 分析EBV在癌症和自身免疫性疾病的发病过程中的作用.
主要成果:
- EBV与淋巴细胞和上皮细胞癌的发展有关.
- EBV感染是自身免疫性疾病,特别是多发性硬化症 (MS) 的重要危险因素.
结论:
- 爱斯坦-巴尔病毒感染的后果对健康造成了巨大的负担.
- 进一步研究EBV在癌症和自身免疫性疾病中的作用是有必要的.
相关概念视频
Stages of Infection
59.0K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
59.0K
Immunodeficiency Diseases
1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.2K
Immune Response Against Viral Pathogens
917
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
917
Factors Affecting the Risk of Infection
12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
Development of Immunocompetence
448
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
448
Immunological Memory
4.9K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
4.9K


