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酸盐暴露,氧化应激和高血压风险:在中国普通人口中探索关联和调解效应

Xueting Shi¹, Ying Zhang¹, Ye Li¹

¹Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, China.

Ecotoxicology and environmental safety

|August 15, 2025

概括

甲酸盐暴露与高血压风险增加和血压升高有关. 氧化应激生物标志物,8-基-2-脱氧氨酸和甲,部分调解了这种关系,表明甲酸诱导的心血管影响的作用.

科学领域:

环境健康环境健康
心血管流行病学心血管流行病学
毒理学毒理学毒理学

背景情况:

酸盐是广泛使用的增塑剂,可疑与代谢和心血管疾病有关.
流行病学证据,特别是在高血压方面,仍然有限.
氧化应激是一种潜在的机制,将环境暴露与慢性疾病联系起来.

研究的目的:

调查甲酸盐暴露与高血压风险和血压水平之间的关联.
探索氧化应激在这种关联中的调解作用.
为了确定有助于高血压风险的特定甲酸代谢物.

主要方法:

在中国武汉1199名成年人的横截面研究.
测量尿甲酸代谢产物和氧化应激生物标志物 (8-基-2-脱氧氨酸,马隆迪化物).
统计分析,包括加权量素和和 (WQS) 和调解模型.

主要成果:

在多个酸盐代谢物 (MEP,MBP,MiBP,MBzP) 和酸盐总和 (ΣPAE) 与高血压风险和血压升高之间发现了积极的关联.
甲基甲酸盐 (MEP) 被确定为混合物诱导的高血压风险的关键因素.
酸盐暴露与氧化应激生物标志物增加有关,这部分介导了对高血压和血压的影响.

结论:

甲酸暴露与高血压和高血压的风险增加有关.
氧化应激,包括DNA损伤和脂质过氧化,可能是重要的介导途径.
研究结果强调了甲酸盐暴露的潜在心血管风险,以及氧化应激在潜在机制中的重要性.

关键词:

血压血压血压血压在高血压的高血压.调解调解是一种调解.氧化应激是一种氧化应激.甲酸是一种甲酸.

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