激发性驱动到球外段的刺激驱动促进非人类灵长类动物的行动启动
Atsushi Yoshida1, Okihide Hikosaka2
1Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA; Systems Neuroscience Laboratory, Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan.
Current biology : CB
|August 15, 2025
概括
灵长类动物的白球体 (GPe) 的外部部分积极促进行动并抑制运动. 这种基底腺核在运动控制中起着双重作用,挑战了以前仅限抑制的观点.
科学领域:
- 神经科学是一个神经科学.
- 灵长类神经生理学
- 基底性 Ganglia 研究 研究
背景情况:
- 传统上,人们认为白球体 (GPe) 的外部部分仅通过基底质的间接途径来调解运动抑制.
- 最近的动物研究表明,GPe也可能积极促进行动,表明更复杂的功能作用.
研究的目的:
- 调查灵长类GPe是否表现出超出运动抑制的功能多样性.
- 探索GPe在灵长类动物中基于奖励的决策过程中的行动启动和抑制中的作用.
主要方法:
- 记录了子的单单元活动,它们执行了一个新的顺序选择任务.
- 任务设计通过要求对象的接受或拒绝来分离行动的启动和抑制.
- 利用尾部背部GPe.Pe.中的谷氨酸受体的局部药理学阻塞.
主要成果:
- 在GPe中确定了三个不同的神经元集群,与行动相关的各种发射模式.
- 集群1和2与行动促进相关,而集群2对"好"物体进行了选择.
- 集群3显示在"坏"物体排斥期间的抑制;药物锁损害了萨卡德启动和排斥.
结论:
- 灵长类GPe同时调解运动促进和主动抑制,扩大其已知的功能.
- 这些发现凸显了在基底腺网络中特征化电路和细胞类型特定作用的必要性.
- 结果对理解基于奖励的决策过程中的正常运动控制和运动障碍有影响.
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