右尾海马中的结构功能连接合介导体质指数对认知功能的影响
Wenjie Xia1, Shanling Ji2, Defu Zhang2
1Cheeloo College of Medicine, Shandong University, Shandong, Jinan 250000, China.
Journal of affective disorders
|August 15, 2025
概括
高体重指数 (BMI) 通过改变大脑结构功能连接 (SC-FC) 合,影响认知功能. 这些SC-FC模式的变化可以对认知表现产生负面和积极的影响.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 肥胖问题研究研究
背景情况:
- 体重指数 (BMI) 表示的肥胖与认知能力下降有关.
- 影响BMI与认知功能关系的神经机制尚未完全理解.
- 大脑结构功能连接 (SC-FC) 合是一种潜在的调解器.
研究的目的:
- 调查BMI,认知功能和SC-FC合之间的关系.
- 检查SC-FC合如何调解BMI和认知表现之间的关联.
- 确定SC-FC合受BMI影响的特定大脑区域.
主要方法:
- 在490名健康成年人身上利用休息状态功能性MRI (rs-fMRI) 和扩散张力成像 (DTI).
- 构建结构连接 (SC) 来自DTI和功能连接 (FC) 来自rs-fMRI.
- 计算了SC-FC合,并进行了调解分析,以评估BMI通过SC-FC对认知的影响.
主要成果:
- 体重指数显示出与认知测试的不同相关性,包括流性,TMT-A,WMS-III-SS,BACS-SC,BVMT-R和NAB-Mazes.
- 较高的BMI与右尾海马 (cHipp) 和中回 (MTG) 中的SC-FC增加有关.
- 右侧的SC-FC合cHipp和MTG调解了BMI对特定认知功能的影响,例如流性和NAB-Mazes表现.
结论:
- 体重指数通过大脑SC-FC合的改变影响认知功能.
- 像海马体和状环这样的区域的特定SC-FC模式介导认知结果.
- 这些发现突显了BMI对神经连接介导的认知有明显的有害和有益影响.
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