生物年龄加速预测骨质疏松症和减少长寿在一个大前景队列中的预测
Rui Zhang1, Wanyang Zhong1, Yuelan Gao2
1Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Bone
|August 15, 2025
概括
加快的生物衰老预测骨质疏松症并缩短寿命. 这一发现表明,生物衰老加速 (BAA) 可以改善早期风险识别,并为骨健康提供信息干预.
科学领域:
- 老年学是一门学科.
- 肌肉骨健康 肌肉骨健康
- 生物标志物 生物标志物
背景情况:
- 骨质疏松症是一种常见的与年龄相关的疾病,但仅仅是时间学年龄不足以预测风险.
- 生物衰老加速 (BAA) 可能为预测骨质疏松症和缩短寿命提供更准确的生物标志物.
研究的目的:
- 研究生物衰老加速 (BAA) 与患骨质疏松症的风险之间的关联.
- 为了检查BAA和全因死亡率之间的关系.
- 评估BAA和多基因风险评分 (PRS) 对骨质疏松风险的综合影响.
主要方法:
- 分析了来自293224名骨质疏松症免费参与者的英国生物库数据.
- 使用克莱梅拉-双方法生物年龄 (KDM-BA) 和PhenoAge模型估计BAA.
- 多变量考克斯模型评估BAA和PRS与发生骨质疏松症和死亡率的关联.
主要成果:
- 增加的BAA (KDM-BA和PhenoAge加速) 与发生骨质疏松症的更高风险显著相关.
- 在BAA的最高三位数显示,与最低三位数相比,骨质疏松症的风险增加了38-43%.
- 高BAA和高PRS显示出强烈的附加效应,几乎使骨质疏松症风险增加了三倍.
- 加速衰老与45岁预期寿命减少1.3-1.8年有关.
结论:
- 加快的生物衰老是骨质疏松症和过早死亡的独立预测因素.
- 将BAA纳入临床评估可以改善早期识别患有骨质疏松症风险的个体.
- BAA评估可以支持针对性干预,以保持骨健康和促进健康的衰老.
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