健身和运动对大脑年龄的影响:一项随机临床试验
Lu Wan1, Cristina Molina-Hidalgo1, Mary E Crisafio2
1AdventHealth Research Institute, Neuroscience Institute, Orlando, FL 32084, USA.
Journal of sport and health science
|August 15, 2025
概括
在早期到中年成人中,定期进行有氧运动可以降低大脑年龄. 这项为期12个月的研究发现,中度至强度的体力活动改善了心肺呼吸能力,并减少了大脑预测年龄差异 (大脑-PAD).
科学领域:
- 神经科学是一个神经科学.
- 运动生理学 运动生理学
- 衰老研究研究 衰老研究
背景情况:
- 中年人的生活方式因素会影响晚年人的大脑健康.
- 在成年早期和中期,有氧运动对结构性大脑健康的影响尚不清楚.
- 这项研究研究了有氧运动对大脑年龄和潜在的介导因素的影响.
研究的目的:
- 为了确定12个月的中度至强度有氧运动干预对大脑预测年龄差异 (大脑-PAD) 的影响.
- 探索心肺呼吸能力 (CRF) 是否调解有氧运动和大脑-PAD之间的关系.
- 为了检查健康的早期到中年成年人脑PAD和CRF的变化.
主要方法:
- 一个为期12个月的单盲随机临床试验,涉及130名26-58岁的健康成年人.
- 参与者被随机分配到监督的中度至强度有氧运动组 (150分钟/周) 或常规护理对照组.
- 大脑预测年龄差异 (大脑-PAD) 和心肺呼吸能力 (CRF,以VO2峰值衡量) 在基线和12个月后被评估.
主要成果:
- 与对照组相比,有氧运动组显示大脑PAD显著减少 (p=0.019).
- 与对照组相比,运动组的心肺呼吸能力 (VO2峰值) 在运动组显著改善 (p=0.015).
- 没有观察到身体组成,血压或来自大脑的神经营养因子水平的显著变化;建议的调解途径在统计学上没有显著意义.
结论:
- 十二个月的中度至强度有氧运动有效地减少了早期到中年成人的大脑PAD.
- 有氧运动干预导致心肺呼吸能力的改善.
- 通过有氧运动影响大脑年龄的特定生物途径尚未被阐明.
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