听觉调节海马运动回路通过非正规的网膜-边缘路径
Jessica Winne1, George Nascimento2, Rafael Pedrosa3
1Neurodynamics Lab, Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil; Hearing and Neuronal activity lab, Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil; Department of Biology, University of Maryland, College Park, United States.
Progress in neurobiology
|August 15, 2025
概括
响亮的声音会在运动期间影响海马,通过通过大脑干路径改变大脑波活动,而不是听觉皮层. 这种声学处理有助于适应性行为的运动集成.
科学领域:
- 神经科学是一个神经科学.
- 审计处理 审计处理
- 机车运动 机车运动
背景情况:
- 快速检测听觉刺激对于适应性行为至关重要,特别是在运动过程中.
- 运动诱导的听觉皮质活动的抑制提出了关于突出声音如何影响运动回路的问题.
研究的目的:
- 研究神经通路,将大声传递到背部海马体 (dHPC) 的神经通路,并调节移动期间的振动.
- 阐明听觉信息影响运动回路的机制,独立于主要听觉皮层.
主要方法:
- 在体内摄取的成像.
- 电子生理学 电子生理学
- 化学和光遗传学.
- 听觉刺激是一种听觉刺激.
主要成果:
- 大声的宽带噪声加速了 teta 频率,并降低了 dHPC 中的功率,通过脑内皮层 (EC) 和中间隔膜 (MS) 输入的介导.
- 脊内核 (DCN) 的神经元向庞丁网状核 (PRN) 投射的激活模仿了噪音驱动的海马反应,表明大脑干-边缘路线.
- 噪音调节CA1金字塔神经元和内部神经元活动,并增加dHPC和中间前额叶皮层 (mPFC) 之间的theta连贯性,增强区域间同步.
结论:
- 背腔耳核 (DCN) 过行为相关的声音,促进运动期间海马体中的声学-运动集成.
- 这条通往海马的听觉处理途径与主要听觉皮层独立运作.
- 这些发现揭示了通过脑干-海马体电路将听觉信息与运动控制相结合的机制.
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