对于白噪声和频率受限制的声音,小鼠上层结核中的听觉响应神经元的表征
Yufei Si1, Brian R Mullen1, Greta Vargova1
1Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064.
概括
上层结核 (SC) 使用不同的听觉神经元类来处理声音定位,对幼儿呼叫的反应与白噪声不同,并且不显示地形组织.
科学领域:
- 神经科学是一个神经科学.
- 审计处理 审计处理
- 传感器运动集成的整合.
背景情况:
- 上 (SC) 对于声音定位至关重要,形成听觉空间的地形图.
- 以前的研究集中在白噪声刺激上,揭示了用于空间受感场生成的特定线索.
- SC对光谱限制的自然声音的反应及其对地形绘图的影响仍然不清楚.
研究的目的:
- 为了研究高级结核 (SC) 神经元如何对频率受限的自然主义声音做出反应.
- 确定这些反应是否会改变SC受体场和地形图的组织.
- 根据光谱时间性质,在SC内识别和分类听觉神经元类型.
主要方法:
- 从小鼠SC神经元进行大规模的体内生理记录.
- 用宽带白噪声进行刺激,自然超声波小狗的叫声和声.
- 神经元反应的分析,包括时间模式,空间偏好和光谱时间受体场 (STRF) 特性.
主要成果:
- 听觉神经元对小狗的叫声和声表现出不同的时间反应和空间偏好.
- 在SC中确定了四类听觉响应神经元,它们位于前后轴沿.
- 对幼犬呼叫的听觉反应没有以地形组织,与对白噪声的反应不同.
结论:
- 听觉系统根据听觉源的光谱内容采用不同的声音定位策略.
- 虽然幼犬呼叫响应没有被拓地绘制,但人口活动仍然可以预测刺激位置.
- 不同类型的听觉神经元有助于SC中的声音处理,具有不同的空间和光谱时间调.
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