睡眠呼吸暂停严重程度与阻塞性睡眠呼吸暂停患者轻度认知障碍之间的关系
Shuxin Guo1, Chunguang Liang2, Jinrui Fei1
1Department of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
BMC psychiatry
|August 15, 2025
概括
严重的阻塞性睡眠呼吸暂停 (OSA),睡眠质量差以及过度的白天嗜睡与轻度认知障碍 (MCI) 的更高风险有关. 这项研究强调了导致OSA患者认知能力下降的关键因素.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 认知科学 认知科学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 越来越多地被认为对认知功能的影响.
- 需要进一步调查OSA严重程度,睡眠质量,白天嗜睡和轻度认知障碍 (MCI) 之间的关系.
研究的目的:
- 调查OSA严重程度与MCI发病率之间的关联.
- 为了确定白天嗜睡和夜间睡眠质量是否与OSA患者的MCI相关.
主要方法:
- 一项涉及387名OSA患者的横截面研究,这些患者通过多睡眠学或家庭睡眠呼吸暂停测试进行诊断.
- 患者被分为正常认知功能 (NC) 和MCI组 (蒙特利尔认知评估得分<26).
- 呼吸暂停-呼吸暂停指数 (AHI),氧气不和指数 (ODI),爱普沃思睡眠度量表 (ESS) 和匹兹堡睡眠质量指数 (PSQI) 用于评估. 多变量逻辑回归分析了相关性.
主要成果:
- 38%的OSA患者表现出MCI.
- 严重的OSA (AHI ≥30/h),睡眠质量差 (PSQI ≥9) 和显著的白天嗜睡 (ESS ≥11) 独立地与患MCI风险增加有关.
- 未经调整的分析显示,MCI的睡眠呼吸暂停严重程度,白天嗜睡和睡眠质量存在正相关性,但在控制混因子后,这些并不显著.
结论:
- 严重的阻塞性睡眠呼吸暂停,夜间睡眠质量差,白天嗜睡是OSA患者轻度认知障碍的重要危险因素.
- 这些发现强调了解决睡眠障碍的重要性,以潜在地减轻OSA患者的认知衰退.
更多相关视频
相关概念视频
Sleep Apnea
220
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
220
Insufficient Sleep and Sleep Deprivation
210
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
210
Substance Use Disorders Affecting Sleep
217
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
217
Sleep-Wake Cycles
1.6K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.6K
Sleepwalking and Sleep Talking
314
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
314
Alzheimer's Disease: Overview
668
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
668


