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在第二代抗精神病药物类别中,因因克雷类减肥药的体重变化
Jithin Sam Varghese1,2, David R Goldsmith3, Robert O Cotes3
1Emory Global Diabetes Research Center of Woodruff Health Sciences Center and Emory University, Atlanta, GA, USA. jvargh7@emory.edu.
International journal of obesity (2005)
|August 15, 2025
概括
在服用第二代抗精神病药物 (SGA) 的患者中,以因克雷丁为基础的减肥药有效降低体重. 然而,在SGA的个人中,体重减轻的程度较低,预计抗精神病药物诱导的体重增加 (AIWG) 较高.
科学领域:
- 药理学 药理学是指药理学的学科.
- 代谢医学是一种代谢医学.
- 精神病学是一个精神病学.
背景情况:
- 第二代抗精神病药物 (SGA) 经常与显著的体重增加有关,这是一个常见的副作用,影响患者的坚持和代谢健康.
- 抗精神病药物诱导的体重增加 (AIWG) 在不同的SGA药物中有所不同,需要定制的管理策略.
研究的目的:
- 为了评估基于因克雷丁的减肥药物的疗效,患者被处方SGA.
- 分析体重变化和实现至少5%体重减轻的可能性,基于规定的SGA的预期AIWG类别.
主要方法:
- 从2021年6月到2023年12月使用电子健康记录的回顾性队列研究.
- 纳入标准:没有糖尿病的成年人 (≥18岁),处方SGA,并有资格服用基于素的减肥药物.
- 分析体重变化 (千克) 和6个月体重减轻≥5%的概率,按SGAAIWG类别分层 (高,中,低).
主要成果:
- 这项研究包括66,574名成年患者,平均BMI为39.5kg/m2.
- 服用因克雷丁基药物的患者平均减轻了-2.17公斤,并且实现5%体重减轻的可能性是1.71倍.
- 与高AIWG SGA (-1.33 公斤) 患者相比,在低AIWG SGA (-3.02 公斤) 的患者中,体重减轻更为显著.
结论:
- 基于因克雷丁的药物,如西马格卢提德和蒂尔泽帕提德,在使用SGA的患者中促进体重减轻.
- 这些减肥药的有效性降低了在患者处方SGA与AIWG更高的倾向.
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