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较低的饮食质量加快了基于DNA甲基化的年龄

Botong Shen¹, Nicole Noren Hooten¹, Nicolle A Mode¹

¹Laboratory of Epidemiology and Population Sciences, National Institute On Aging, National Institutes of Health, 251 Bayview Boulevard Suite 100 Room 4C-222, Baltimore, MD, 21224, USA.

|August 15, 2025

概括

较低的饮食质量加快了生物衰老,这是通过DunedinPACE (Dunedin Pace of Aging Calculated from the Epigenome) 测量的. 这项研究将不良饮食与多样化的成年人在五年内更快的表观遗传衰老联系在一起.

科学领域:

表观遗传学和衰老研究研究.
营养流行病学营养流行病学
纵向健康研究纵向健康研究

背景情况:

根据表观基因组计算的衰老速度 (DunedinPACE) 是一种与健康寿命相关的DNA甲基化生物标志物.
关于饮食质量对不同人群,特别是非裔美国人和白人成年人的DunedinPACE影响的研究有限.

研究的目的:

在非洲裔美国人和白人成年人队伍中调查饮食质量和DunedinPACE之间的纵向关系.
为了确定饮食模式是否会在五年内影响表观遗传衰老.

主要方法:

利用了421名成年人 (30-64岁) 的纵向数据,根据种族,性别和贫困状况进行了平衡.
在两个时间点使用饮食炎症指数 (DII) 和健康饮食指数-2010 (HEI) 评估饮食质量.
采用线性混合效应模型来分析DII,HEI和DunedinPACE之间的关联,对共变量进行调整.

主要成果:

较高的DII分数 (表明一种更有利于炎症的饮食) 与较高的DunedinPACE分数 (更快的衰老) 有显著的关联.
更高的HEI得分 (表明更好的饮食质量) 与较低的DunedinPACE得分 (更慢的衰老) 有显著的关联.
这些关联在为期五年的研究期间保持一致,最初的队列数据显示了促炎性饮食模式和饮食质量低下.

结论:

较低的饮食质量独立地与更快的表观遗传衰老 (DunedinPACE) 相联系.
饮食质量在与健康衰老相关的表观遗传机制中起着重要作用.
研究结果强调了饮食在调节不同人群生物衰老过程中的重要性.

关键词:

通过DNA甲基化.饮食指数饮食指数饮食质量饮食质量饮食分数的分数是多少在健康方面存在差异.炎症炎症是一种炎症.少数群体的健康问题种族种族种族种族

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