Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Epigenetic Regulation01:37

Epigenetic Regulation

3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.1K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Association of mitochondrial DNA haplogroup, oxidative DNA damage and inflammatory markers in middle-aged adults.

International journal of radiation biology·2026
Same author

Longitudinal analysis of cytokines, chemokines, and inflammatory markers in a middle-aged cohort.

GeroScience·2026
Same author

Healthy Eating Index, Epigenetic Age Acceleration and Mortality Risk in US Adults.

Aging cell·2026
Same author

Epigenetic aging markers in the association between frailty and mortality among U.S. adults.

BMC medicine·2026
Same author

Metabolic signatures, vitamin D, and red cell distribution width in dementia risk: UK Biobank insights.

GeroScience·2026
Same author

Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations.

HGG advances·2026

相关实验视频

Updated: Sep 11, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.7K

较低的饮食质量加快了基于DNA甲基化的年龄.

Botong Shen1, Nicole Noren Hooten1, Nicolle A Mode1

  • 1Laboratory of Epidemiology and Population Sciences, National Institute On Aging, National Institutes of Health, 251 Bayview Boulevard Suite 100 Room 4C-222, Baltimore, MD, 21224, USA.

GeroScience
|August 15, 2025
PubMed
概括

较低的饮食质量加快了生物衰老,这是通过DunedinPACE (Dunedin Pace of Aging Calculated from the Epigenome) 测量的. 这项研究将不良饮食与多样化的成年人在五年内更快的表观遗传衰老联系在一起.

关键词:
通过DNA甲基化.饮食指数 饮食指数饮食质量 饮食质量饮食分数的分数是多少在健康方面存在差异.炎症 炎症是一种炎症.少数群体的健康问题种族 种族 种族 种族

更多相关视频

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

18.9K
Methodology for Accurate Detection of Mitochondrial DNA Methylation
12:11

Methodology for Accurate Detection of Mitochondrial DNA Methylation

Published on: May 20, 2018

13.5K

相关实验视频

Last Updated: Sep 11, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.7K
Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

18.9K
Methodology for Accurate Detection of Mitochondrial DNA Methylation
12:11

Methodology for Accurate Detection of Mitochondrial DNA Methylation

Published on: May 20, 2018

13.5K

科学领域:

  • 表观遗传学和衰老研究研究.
  • 营养流行病学 营养流行病学
  • 纵向健康研究 纵向健康研究

背景情况:

  • 根据表观基因组计算的衰老速度 (DunedinPACE) 是一种与健康寿命相关的DNA甲基化生物标志物.
  • 关于饮食质量对不同人群,特别是非裔美国人和白人成年人的DunedinPACE影响的研究有限.

研究的目的:

  • 在非洲裔美国人和白人成年人队伍中调查饮食质量和DunedinPACE之间的纵向关系.
  • 为了确定饮食模式是否会在五年内影响表观遗传衰老.

主要方法:

  • 利用了421名成年人 (30-64岁) 的纵向数据,根据种族,性别和贫困状况进行了平衡.
  • 在两个时间点使用饮食炎症指数 (DII) 和健康饮食指数-2010 (HEI) 评估饮食质量.
  • 采用线性混合效应模型来分析DII,HEI和DunedinPACE之间的关联,对共变量进行调整.

主要成果:

  • 较高的DII分数 (表明一种更有利于炎症的饮食) 与较高的DunedinPACE分数 (更快的衰老) 有显著的关联.
  • 更高的HEI得分 (表明更好的饮食质量) 与较低的DunedinPACE得分 (更慢的衰老) 有显著的关联.
  • 这些关联在为期五年的研究期间保持一致,最初的队列数据显示了促炎性饮食模式和饮食质量低下.

结论:

  • 较低的饮食质量独立地与更快的表观遗传衰老 (DunedinPACE) 相联系.
  • 饮食质量在与健康衰老相关的表观遗传机制中起着重要作用.
  • 研究结果强调了饮食在调节不同人群生物衰老过程中的重要性.