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Updated: Sep 11, 2025

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
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Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

Published on: August 28, 2012

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揭示了粉样蛋白前体蛋白细胞内域的结构格局

Nabanita Mandal1, Marie Skepö2

  • 1Division of Computational Chemistry, Department of Chemistry, Science for Life Laboratory, Lund University, Lund, Sweden.

Biophysical journal
|August 16, 2025
PubMed
概括

粉样前体蛋白细胞内域 (AICD) 是结构灵活的,在紧和扩展状态之间波动. 这种可塑性是其在核信号传递和神经退行性疾病 (如阿尔茨海默氏症) 中发挥作用的关键.

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