相关实验视频
Updated: Sep 11, 2025
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Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
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基因特异性ctDNA动态预测ESCC中的瘤负担和生存结果:一个前性队列研究
Rentong Gu1,2, Tao Liu3, Wen Cheng1
1Department of Thoracic Surgery, Changhai Hospital, Naval Medical University, Shanghai, China.
Clinical and translational medicine
|August 16, 2025
概括
在食道状细胞癌 (ESCC) 中循环瘤DNA (ctDNA) 突变提供了预后见解. 手术前的PTENctDNA阳性强烈预测ESCC患者的侵袭性疾病和低生存率.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 遗传学 是一个遗传学.
背景情况:
- 食道状细胞癌 (ESCC) 是一种具有攻击性的癌症,缺乏有效的生物标志物来监测瘤负担和预后.
- 循环瘤DNA (ctDNA) 显示了实时疾病评估的潜力,但其在ESCC中的实用性尚未得到研究.
研究的目的:
- 调查ctDNA在评估瘤负担和预后的临床实用性,在经过彻底手术的前不治疗的ESCC患者中.
- 评估特定ctDNA突变与临床病理学特征和生存结果之间的关联.
主要方法:
- 54名以前未接受过治疗的ESCC患者的前性队列研究.
- 使用61基因小组分析手术前和手术后的ctDNA.
- ctDNA突变与临床病理学数据和生存指标 (DFS,OS) 的相关性.
主要成果:
- 在96.3%的患者中检测到手术前ctDNA突变,TP53,PIK3CA和PTEN是最常见的.
- 术后对TP53的ctDNA阳性预测了更糟糕的DFS和OS.
- 术前PTENctDNA阳性是不良DFS和OS的最强的独立预测因素,优于TNM分期.
结论:
- ctDNA分析动态反映ESCC瘤负担和预后.
- 基因特异性ctDNA突变 (TP53,PIK3CA,PTEN) 在ESCC中具有显著的预后价值.
- 手术前的PTENctDNA阳性可以识别高风险患者,有助于风险分层和个性化治疗.
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