老年妇科癌症患者的免疫疗法:重新考虑年龄作为限制因素
Yoshio Yoshida1, Makoto Orisaka1, Daisuke Inoue1
1Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Expert opinion on pharmacotherapy
|August 16, 2025
概括
免疫检查点抑制剂 (ICI) 在老年癌症患者中显示出显著的生存益处,与年轻人群相比. 谨慎的选择和管理是优化老年人群ICI治疗的关键.
科学领域:
- 老年瘤学 老年瘤学
- 免疫疗法研究 免疫疗法研究
- 癌症治疗方法 癌症治疗方法
背景情况:
- 全球人口老龄化需要了解免疫检查点抑制剂 (ICI) 对老年癌症患者的有效性和安全性.
- 与年龄相关的免疫变化 (免疫发生) 可能会影响ICI的有效性,需要进行彻底的调查.
研究的目的:
- 审查当前的临床和临床前证据,以了解衰老如何影响ICI反应.
- 综合关于ICI有效性,安全性和与免疫相关的不良事件 (irAEs) 在老年人中的各种癌症的数据.
主要方法:
- 临床和临床前研究的全面审查,包括元分析和现实世界的数据.
- 分析与年龄相关的免疫变化,瘤微环境变化和临床前衰老模型.
- 对ICI在老年癌症患者的疗效和安全性进行临床试验结果的检查.
主要成果:
- 临床数据表明ICI提供了显著的生存益处,并且在选择的老年患者中通常耐受良好.
- 老年人的ICI结果通常与年轻人队伍相似,尽管根据癌症类型,性能状态 (PS) 和生物标志物而异.
- 与免疫相关的不良事件 (irAEs) 需要对伴随性疾病进行管理,但在老年人中并不总是更高.
结论:
- 考虑到生物年龄,PS和并发症的个性化治疗决策对于优化老年患者的ICI治疗至关重要.
- 未来的研究应该确定生物标志物和定制策略,以加强ICI在老年癌症患者中的使用.
关键词:
衰老的衰老 衰老的衰老癌症免疫疗法免疫疗法老年瘤学是一门老年瘤学.免疫检查点抑制剂 (ICI)与免疫相关的不良事件 (IRAE)免疫性 免疫性 免疫性年龄较大的成年人.瘤微环境 (TME) 是指瘤的微环境.更多相关视频
06:49Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
Published on: February 12, 2018
11.0K
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
12.3K
相关概念视频
01:27Tumor Immunotherapy
660
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
660
01:30Cancer Vaccines
509
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
509
02:49Cancer Therapies
7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
02:50Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K