局部化物用于预防化区域儿童的化:一项随机临床试验
S He1,2, D Duangthip3, C H Chu2
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Journal of dental research
|August 16, 2025
概括
半年一次使用38%的白银二胺化物 (SDF) 和5%的化 (NaF) 漆,可以有效地预防母牙腔. 与安慰剂相比,这两种治疗都显示出类似的有效性,SDF和NaF之间没有显著差异.
科学领域:
- 儿科牙科 儿科牙科
- 皮肤病学 皮肤病学 皮肤病学
- 预防性牙科 预防性牙科
背景情况:
- 牙腐烂是学龄前儿童中普遍存在的一种慢性疾病,特别影响主要的牙.
- 早期干预策略对于管理和预防幼儿病进展至关重要.
研究的目的:
- 为了比较38%的白银二化物 (SDF) 和5%的化 (NaF) 漆的半年应用的有效性,防止初级牙中的闭塞腔.
- 在30个月的时间内,对这些预防药物与安慰剂进行评估.
主要方法:
- 一个为期30个月的,并行,三臂,双盲,随机对照试验,涉及791名学龄前儿童 (大约3岁).
- 参与者被分配接受半年一次38%的SDF溶液,5%的NaF涂漆或增强水的局部应用.
- 化水平的化发育是主要结果,使用概括估计方程和多级比例危险模型进行分析.
主要成果:
- 在30个月的皮发病率为25.5% (SDF),24.4% (NaF) 和30.1% (安慰剂) 在儿童水平.
- 在牙层面,发病率为7.5% (SDF),7.6% (NaF) 和9.1% (安慰剂).
- 与安慰剂相比,SDF和NaF都显著降低了腔的几率 (SDF的aOR=0.67,NaF的aOR=0.58;P=0.027),SDF和NaF之间没有显著的有效性差异 (HR=0.97).
结论:
- 半年一次使用38%的SDF和5%的NaF漆,有效防止一次性牙的闭合性虫.
- 在预防空方面,SDF和NaF漆的有效性与安慰剂相当,并且明显优于安慰剂.
- 诸如基线口腔卫生,牙经验和吃零食的频率等因素影响了牙发生率.
相关概念视频
Tooth Anatomy
1.0K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
1.0K
Teeth
681
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
681
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
691
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
691
Substituent Effects on Acidity of Carboxylic Acids
7.1K
The acidity of carboxylic acids is influenced by the nature of the substituents bounded to the functional group. The acid strength is determined by the stability of the carboxylate anion—the conjugate base formed by dissociating the corresponding carboxylic acid.
7.1K
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
1.2K
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
1.2K
Drug Delivery: Enteral Route
719
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
719


