牙周治疗对HbA1c变化的长期影响 在2型糖尿病中的HbA1c变化
H K Chee1,2, S H X Tan3, G H E Tjakkes2
1National Dental Centre Singapore, Singapore.
Journal of dental research
|August 16, 2025
概括
非手术性牙周治疗 (NSPT) 在患有牙周炎的2型糖尿病 (T2D) 患者中显著改善了血糖控制. 这种治疗导致HbA1c水平持续下降,特别是在基线葡萄糖水平较高的患者中.
科学领域:
- 牙周病学和内分泌学.
- 研究口腔健康和全身疾病管理之间的双向关系.
背景情况:
- 以前关于非手术性牙周治疗 (NSPT) 和2型糖尿病 (T2D) 的血糖控制的研究往往是短期的,并且未能解释糖尿病药物调整.
- 了解NSPT对T2D患有牙周炎的患者血糖管理的长期影响,对于全面的患者护理至关重要.
研究的目的:
- 纵向评估NSPT对T2D患者HbA1c水平和牙周健康的影响.
- 为了考虑到研究期间糖尿病药物使用的变化.
主要方法:
- 一项纵向队列研究,涉及154名患有牙周炎的T2D患者,在12个月内接受NSPT和定期随访护理.
- 在基线和定期间隔进行全面的牙周检查和HbA1c监测.
- 使用线性混合效应模型进行统计分析,以控制混因素,包括药物变化.
主要成果:
- 在治疗后3-12个月内,NSPT导致平均HbA1c水平显著降低,从0.68%到0.77%不等.
- 在牙周参数中观察到明显的改善,包括12个月后牙周炎症表面积 (PISA) 减少352.7mm2.
- 基线HbA1c>8.0%的患者与可接受水平 (0.24%) 的患者相比,经历了更显著的HbA1c降低 (1.31%)
结论:
- 包括维护在内的非手术性牙周治疗有效改善2型糖尿病患者的血糖结果.
- 在T2D患者中,NSPT对血糖控制的益处特别明显,T2D患者最初的HbA1c水平较高 (>8.0%).
- 这项研究强调了将牙周护理整合到2型糖尿病管理中的重要性,以改善全身健康.
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