年轻和中年男性的脊椎骨分数的变化及其决定因素:一项纵向观察性研究
Yaël Sertons1, Thiberiu Banica1, Stefan Goemaere1,2
1Department of Endocrinology, Ghent University Hospital & Department of Internal Medicine and Pediatrics, Ghent University, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
The Journal of clinical endocrinology and metabolism
|August 16, 2025
概括
在健康的年轻男性中,肌骨分数 (TBS) 降低,即使骨周转率标志物正常. 雌激醇和自由等性类固醇与基线TBS有关,但与时间的推移无关.
科学领域:
- 骨生物学和新陈代谢
- 内分泌学 在内分泌学.
- 骨质疏松症的研究研究.
背景情况:
- 脊椎骨评分 (TBS) 评估骨微观结构,这是骨强度的一个关键因素.
- 骨周转标记物 (BTM) 和性类固醇在骨健康中起作用.
- 了解年轻男性的TBS变化对于早期发现骨质损失至关重要.
研究的目的:
- 为了研究骨循环标记物 (BTM) 和性类固醇与男性的肌骨评分 (TBS) 之间的关系.
- 分析TBS的纵向变化及其决定因素在健康男性队列.
主要方法:
- 这是一项基于人口的纵向研究,对465名25-45岁的健康男性进行了研究.
- 腰椎TBS使用TBS iNsight®软件进行了计算.
- 测量了性类固醇 (,雌激素) 和BTM;统计分析使用了线性混合效应建模.
主要成果:
- 基线TBS与自由丸激素,自由雌激素和总雌激素有关,但与总丸激素或BTM无关.
- 在12年半的时间里,TBS下降了1.43%.
- 较高的BMI和干部脂肪预测了更大的TBS下降,而性类固醇和BTM水平/变化与TBS变化无关.
结论:
- 在年轻和中年健康男性中,TBS减少,这表明骨微观结构的早期变化.
- 虽然基线性类固醇水平与TBS相关,但它们不能预测其下降.
- 需要进一步的研究才能充分阐明青少年TBS变化背后的机制.
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