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Updated: Sep 11, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
心血管疾病中的南亚代表性随机对照试验:系统性审查
Nishant Uppal1, Aniruddh P Patel2, Deepak L Bhatt3
1Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
南亚人在心血管疾病 (CVD) 临床试验中的代表性不足. 这一系统性审查强调,迫切需要增加南亚人参与心血管疾病随机对照试验 (RCT).
科学领域:
- 心脏病学 心脏病学
- 临床试验 临床试验
- 健康差异 在健康上的差异
背景情况:
- 南亚人占全球人口的25%,患心血管疾病 (CVD) 的风险增加.
- 在心血管疾病 (CVD) 随机对照试验 (RCT) 中,南亚人口的代表性尚不清楚.
- 了解这种表征对于解决心血管疾病的健康差异至关重要.
研究的目的:
- 系统地审查和量化主要心血管疾病 (CVD) 随机对照试验 (RCT) 中的南亚代表性.
- 提取这些试验中南亚参与者的随机化后初级结果估计.
主要方法:
- 2018年至2022年间发表的主要心血管疾病 (CVD) 随机对照试验 (RCT) 的系统审查.
- 每项研究的手动选,以确定和量化南亚参与者.
- 在PROSPERO (CRD42023396522) 中预期注册审查协议.
主要成果:
- 包括310个RCT,共有1,036,737名参与者,其中32,764名 (3.2%) 是南亚血统.
- 除了印度的一项大型试验外,南亚的代表性下降到总参与者的1.1%.
- 根据病情的代表性有所不同,冠状动脉疾病试验的含量最高 (9.0%),心力衰竭,心脏骤停或膜心脏病试验没有.
- 随机化后的数据可用于所有具有此类数据的参与者的7.3%.
结论:
- 在主要心血管疾病 (CVD) 随机对照试验 (RCT) 中,南亚人显著不足.
- 迫切需要加强南亚人群在心血管疾病临床试验中的招生计划.
- 需要进一步的研究来确定这种代表性不足是否有助于在这个人口群体中观察到的心血管疾病风险增加.
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