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皮质醇,DHEAS和皮质醇/DHEAS比率作为表观遗传衰老加速的预测因素

Rafaela S C Takeshita^1,2, Amber T Nguyen³, Anthony P Auger³

¹Department of Anthropology, Kent State University, 750 Hilltop Dr, 231 Lowry Hall, Kent, OH, USA. rtakeshi@kent.edu.

|August 16, 2025

概括

测量皮质醇/脱氨-硫酸盐 (DHEAS) 比率为压力和衰老提供了一个比单独皮质醇更准确的生物标志物. 这一比率更好地预测了表观遗传衰老加速,强调了它在衰老研究中的重要性.

科学领域:

内分泌学在内分泌学.
老年学是一门学科.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

皮质醇是一种常见的压力生物标志物,但由于下丘脑-垂体-上腺轴的干扰,单次测量可能会误导.
脱氨硫酸 (DHEAS) 对抗皮质醇,使其共同测量成为评估压力和衰老的潜在改进.

研究的目的:

检查年龄,性别和生物社会群体如何影响DHEAS,皮质醇及其比例.
确定这些激素是否预测表观遗传年龄和表观遗传年龄加速 (EAA).
为了比较DHEAS,皮质醇和它们对表观遗传衰老的比率的预测性表现.

主要方法:

分析了969名美国中年研究人员的数据.
研究年龄,性别和自我认同的生物社会群体 (SIBG) 对荷尔蒙水平的影响.
皮质醇,DHEAS和皮质醇/DHEAS比率的比较,用于使用六个已确定的表观遗传时钟预测表观遗传年龄加速.

主要成果:

年龄,性别和SIBG显著影响了DHEAS,皮质醇和皮质醇/DHEAS比率.
皮质醇/DHEAS比率成为表观遗传钟最强的预测因素,超过了单独的DHEAS和皮质醇.
皮质醇与Hannum表观遗传年龄呈正相关性,而皮质醇/DHEAS比率与Hannum,Horvath2和PhenoAge表观遗传钟以及Hannum EAA.呈正相关性.

结论:

同时测量皮质醇和DHEAS提供了比单个激素测量更可靠的压力和衰老评估.
皮质醇/DHEAS比率是预测表观遗传衰老及其加速的一个有价值的生物标志物.
未来关于压力和衰老的研究应该包括对皮质醇和DHEAS的联合测量.

关键词:

上腺荷尔蒙是什么衰老的生物标志物衰老的生物标志物通过DNA甲基化.脱水埃皮安德罗斯特硫酸盐基因表观时钟是什么?压力反应应对压力.

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