探索牙腐烂的潜在唾液生物标志物:一个系统性审查
M López-Galindo1, W Atashkadeh
1Calle Duque de Calabria nº 17, puerta 1 46005, Valencia, Spain mopauloga@gmail.com.
Medicina oral, patologia oral y cirugia bucal
|August 16, 2025
概括
唾液蛋白生物标志物显示出诊断牙的潜力,18项研究发现牙活跃和无牙个体之间存在显著差异. 由于研究异质性,需要进一步的研究来证实它们的临床价值.
科学领域:
- 口腔健康研究研究 口腔健康研究
- 生物标志物发现发现
- 蛋白质组学是指蛋白质组学.
背景情况:
- 牙损是一种影响口腔健康的普遍非传染性疾病.
- 唾液在牙保护和再生矿物质化方面发挥着至关重要的作用.
- 唾液蛋白和牙腐烂之间的关联需要进一步澄清.
研究的目的:
- 系统地审查和分析唾液蛋白生物标志物与牙损伤之间的关联.
- 提供关于唾液生物标志物的现有研究格局的见解,以评估.
主要方法:
- 2013年1月至2023年12月期间发表的文献的系统综述.
- 搜索的数据库包括PubMed,Scopus和科学网.
- 对21项涉及2000多名参与者的观察性研究进行了分析.
主要成果:
- 在包括的研究中检查了18种不同的蛋白质.
- 在18项研究中,在脏活跃和无脏受试者之间发现了蛋白质表达的显著差异.
- 偏差风险在10项研究中低,在10项研究中中等,在1项研究中高.
结论:
- 唾液生物标志物显示出牙损伤的非侵入性诊断的潜力.
- 为了确定这些生物标志物的临床实用性,需要进行更大规模,更精心设计的研究.
- 研究设计和受试者因素的异质性使元分析复杂化,并影响生物标志物的可靠性.
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