血液转录组变化与长期通过饮用水接触有关 - - 来自玻利维亚安第斯山脉的横截面研究
Ying Yang1, Anastasiia Snigireva1, Jessika Barron2
1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Environment international
|August 16, 2025
概括
饮用水中的慢性暴露会影响基因表达,特别是影响自和免疫细胞. 性别和遗传变异影响这些诱导的血液转录组变化,突出显示新的生物途径.
科学领域:
- 环境健康 环境健康
- 基因组学就是基因组学.
- 毒理学 毒理学 毒理学
背景情况:
- 通过饮用水的慢性无机 (As) 暴露对健康构成重大风险,个体易感性各不相同.
- 玻利维亚饮用水中天然存在的需要了解其对健康的长期影响.
- 长期暴露对代表性不足的人群血液转录基因组的影响在很大程度上仍未被探索.
研究的目的:
- 研究来自玻利维亚安第斯山脉的个体长期暴露于的血液转录组的全基因组变化.
- 为了确定与相关的基因和长期暴露影响的生物途径.
- 探索性别和AS3MT基因型对诱导的转录基因变化的影响.
主要方法:
- 来自玻利维亚安第斯山脉的个体的全血细胞的全转录组分析.
- 测量尿液中的无机代谢物和AS3MT多态的基因定型.
- 应用线性回归模型用于基因识别,细胞解卷和功能注释 (IPA,ClusterProfiler).
主要成果:
- 鉴定了588个与相关的基因,这些基因与下调自和减少活性NK细胞有关.
- 在与癌症发生,氧化应激和女性代谢相关的途径中观察到性别特定的丰富.
- 在DNA复制/扩散 (低A代谢) 或抑制自/DNA损伤 (高效A代谢) 中发现基因型依赖的丰富.
结论:
- 自的途径在暴露反应中起着至关重要的作用,与PI3K/AKT/mTOR和miRNA生物发生相互作用.
- 这项研究揭示了针对玻利维亚人口长期暴露于的新型全基因组mRNA变化.
- 提供了对暴露影响生物通路的基础见解,特别是在代表性不足的群体中.
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