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血清金属水平和NLRP3基因多态与工人的认知功能之间的关联:联合流行病学和遗传学研究

Youxing Li¹, Wenxue Li², Yaqin Pang³

¹Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam, Malaysia; College of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, China.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

|August 16, 2025

概括

血清含量低可能会增加工人的认知功能障碍风险. 特定的NLRP3基因变异增加了对认知能力下降的易感性,特别是在缺乏的情况下.

科学领域:

环境健康环境健康
遗传学遗传学是一个
神经科学是一个神经科学.

背景情况:

金属,基因多态化和认知功能是相互关联的.
工人接触各种金属,可能会影响认知.
在金属诱导的认知影响中NLRP3基因变异的作用需要研究.

研究的目的:

评估工人的血清金属水平和NLRP3基因多态性.
评估这些因素与认知功能之间的关联.
探索金属暴露,基因变异和认知结果之间的潜在相互作用.

主要方法:

在478名工人中进行了横截面调查.
用诱导合等离子体质谱法 (ICP-MS) 测量血清金属水平.
使用蒙特利尔认知评估 (MoCA) 尺度评估认知功能.
统计分析包括GLM,拉索,BKMR和WQS回归.

主要成果:

血清 (Zn) 水平升高与较高的MoCA分数正相关.
在第60百分位以下的金属 (Na, Zn, Co, Mo, Ti, Sr, Ba) 混合物与认知能力的改善有关.
特定的NLRP3基因型 (rs3806265 C/C,rs4612666 C/T和T/T) 与较低的MoCA分数有关.
在NLRP3rs3806265 C/T和rs4612666 C/T基因型的个体中,Zn与MoCA得分呈正相关性.

结论:

血清的减少可能会增加认知功能障碍的风险.
具有特定NLRP3基因型 (rs3806265 C/C,rs4612666 C/T,T/T) 的个体更容易受到认知衰退的影响.
在NLRP3 rs3806265 C/T和rs4612666 C/T基因型的携带者中,缺乏会加剧认知衰退的风险.

关键词:

工人是一些工人.认知功能认知功能基因多形态的多态化金属水平金属水平在NLRP3中,NLRP3是NLRP3中的一个.

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