心脏和肝脏转录组对肉的急性和慢性热应激反应
Zhirui Yang1, Peihao Liu1, Fan Ying2
1Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Poultry science
|August 16, 2025
概括
禽类热应激 (HS) 会导致大量的生产损失. 这项研究揭示了肉心脏和肝脏组织如何在分子上适应急性和慢性HS,确定了改善耐热性的关键基因和途径.
科学领域:
- 动物科学动物科学
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 热应激 (HS) 显著影响家禽生产,影响生长,新陈代谢和生存.
- 了解对HS的分子反应对于开发缓解策略至关重要.
研究的目的:
- 为了研究在急性和慢性热应激下 brojiler 心脏和肝脏组织的转录组差异.
- 为了确定保存和组织特定的分子适应热应激.
主要方法:
- 从暴露于急性 (2h, 38°C) 和慢性 (6h, 38°C) 热应激的 brojlers 的心脏和肝脏组织的差异基因表达 (DEG) 分析.
- 权重基因共同表达网络分析 (WGCNA) 以确定与压力持续时间相关的基因模块.
- 时间聚类来分析动态基因表达转移.
主要成果:
- 慢性HS在两种组织中都比急性HS引起了比急性HS更明显的转录组变化.
- 分享的差异表达基因 (DEGs) 包括热冲击蛋白,抗氧化剂和结构调节剂.
- 组织特异性反应包括心脏中的细胞因子信号传递和蛋白质折叠,以及肝脏中的代谢抑制/细胞骨重塑.
结论:
- 独特和共享的分子机制是肉适应不同持续时间的热应激的基础.
- 结果提供了关于通过营养或遗传干预来增强家禽耐热性的潜在目标的见解.
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