在美国成年人中, perfluoroalkyl 和 polyfluoroalkyl 物质暴露与高胆固醇血症之间的关联:一个横截面研究
Junyi Wang1, Xiaoman Wei2, Sicheng Lu3
1The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing 210023, China; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine for Cancer Prevention and Treatment, Nanjing 210023, China.
Ecotoxicology and environmental safety
|August 16, 2025
概括
高度的 perfluoroalkyl 和多基物质 (PFAS) 与美国成年人的高胆固醇血风险增加有关. 这项研究强调了PFAS暴露与高胆固醇水平之间的关联,强调需要进一步研究.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 是持久性有机污染物,对环境和健康问题越来越关注.
- 以前的证据表明PFAS和脂质水平之间存在联系,但需要对PFAS暴露和高胆固醇血症进行全面分析.
研究的目的:
- 调查单次和多次PFAS暴露与美国成年人中高胆固醇血症患病率之间的关联.
- 确定有助于高胆固醇血风险的特定PFAS化合物.
主要方法:
- 分析了2292名美国成年人的数据 (2015-2018年国家健康和营养检查调查).
- 应用多变量逻辑回归,加权量子量和 (WQS) 回归,量子量g计算 (Qgcomp) 和贝叶斯核机器回归 (BKMR) 模型.
- 评估单个PFAS (PFHxS,PFOA,PFOS) 和混合物与高胆固醇血症患病率之间的关联.
主要成果:
- 在 ln 转换的 PFHxS,PFOA 和 PFOS 暴露与高胆固醇血症患病率之间发现了显著的积极关联.
- WQS和Qgcomp模型证实了联合PFAS暴露对高胆固醇血症的积极影响,PFHxS是主要的贡献者.
- BKMR分析表明,PFAS混合物与高胆固醇血症之间存在积极趋势,包括PFAS之间的相互作用.
结论:
- 较高的PFAS度可能与美国成年人群中高胆固醇血症风险增加有关.
- perfluorohexane sulfonic acid (PFHxS) 已成为混合物中的一个关键贡献者.
- 需要进一步的前性研究来确定因果关系,并更深入地了解这些关系.
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