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Updated: Sep 11, 2025

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高剂量的 Askorbic 酸选择性地诱导 LKB1 缺陷肺癌中的 pyroptosis,并使免疫治疗敏感

Xiangyu Sun1, Xiaoting Cai1, Shangbiao Li2

  • 1Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Cell reports. Medicine
|August 16, 2025
PubMed
概括

高剂量的甲酸 (AA) 可以克服LKB1缺乏的非小细胞肺癌 (NSCLCs) 的免疫检查点抑制剂 (ICI) 耐药性. 这通过诱导热和通过树突细胞成熟增强抗瘤免疫力来发生.

关键词:
在GSDME中,GSDME是GSDME.没有LKB1的肺癌.在Tpexx中使用.卡斯帕斯-3酶是什么意思树突细胞是一种树突细胞.高剂量的甲酸.免疫疗法耐药性 免疫疗法耐药性热致灭 (pyroptosis) 是一种致的过程.有活性氧物种的反应性氧物种.

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