相关实验视频

Updated: May 4, 2026

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

中央多巴胺D2受体激活对整个产后期母亲行为动态变化的差异效应

Yue Teng¹, Ning Ma¹, Junqi Wang²

¹Faculty of Psychology, Southwest University, Chongqing, 400715, China; Key Laboratory of Cognition and Personality, Ministry of Education, 400715, China.

Neuropharmacology

|August 16, 2025

概括

多巴胺D2受体的激活会影响不同大脑区域和产后阶段的母亲行为. 这表明,在母亲的动机和执行控制中,有特定阶段的角色.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
生殖生物学生殖生物学

背景情况:

母亲的行为对于后代的生存至关重要.
神经机制,包括多巴胺D2受体,调节母亲的护理.
多巴胺D2受体在产后晚期母亲行为中的作用尚不清楚.

研究的目的:

调查多巴胺D2受体在产后早期和晚期母亲行为中的特定区域和时间的作用.
探索多巴胺D2受体在腹膜区域 (VTA) 的激活,核 (NAc) 和中间前额叶皮质 (mPFC) 如何影响母亲的护理和偏好.

主要方法:

哺乳大鼠在产后早期 (产后4-5天) 和晚期 (产后13-14天) 接受了多巴胺D2受体激素的微注射到VTA,NAc或mPFC中.
在注射后评估了家庭子中的母体行为 (例如,幼取回,) 和幼与成年雄的偏好.
分析了行为变化,以确定D2受体激活在特定大脑区域和分娩后阶段的影响.

主要成果:

VTA D2激活在产后早期减少了幼的回收,但没有晚期产后影响.
在分娩后期晚期,NAc D2激活会影响母亲的行为和幼的偏好.
mPFC D2激活在两个时期都减少了母亲的行为,并在产后早期增加了对幼和雄的探索.

结论:

多巴胺D2受体在调节母亲行为的过程中发挥区域和时间特定的作用.
在VTA和NAc中的D2受体激活以依赖阶段的方式调节母亲的动机.
在mPFC中的D2受体通过动机和执行控制影响母亲的行为,随着分娩后的时间而变化.

关键词:

多巴胺D(2) 受体受体母亲的行为母亲的行为中部前额叶皮层中部前额叶皮层.核积累的中心 (nucleus accumbens).腹部顶部区域的区域.

更多相关视频

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period

Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period

Published on: April 5, 2024

相关概念视频

Parental Care

Parental Care

Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...