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Updated: Sep 11, 2025

Design and Validation of a Volumetric-extrusion Bioprinter for Bioprinting of Soluble Basement Membrane Extract for Translational Research
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Published on: March 28, 2025

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通过热挤出使用表面修改的可食用生物聚合物增强药物溶解:设计空间方法论

Hwee Jing Ong1, Fernando Alvarez-Nunez2, Rodolfo Pinal3

  • 1Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Drug Product Technologies, Process Development, Amgen Inc., Thousand Oaks, CA 91320, USA.

Journal of pharmaceutical sciences
|August 16, 2025
PubMed
概括

生物树脂固体分散剂 (BDSDs) 使用经过八基糖酸盐修饰的树脂类生物聚合物 (OS-DLB) 增强药物溶解. 配方加工参数显著影响溶解和结晶性,影响因药物特性而异.

关键词:
结晶性是指结晶性是指结晶性.解散 解散 解散 是一个过程.挤出 挤出 挤出多变量分析多变量分析.聚合物生物材料是一种聚合物生物材料.水溶性较差的药物 在水溶性较差的药物通过设计的质量 (QbD)固体的分散 固体的分散溶解化 溶解化

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