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抗血管内皮生长因子注射后的黄斑孔:一篇综述

Vivian Rajeswaren¹, Vichar Trivedi¹, Pradeepa Yoganathan²

¹Department of Ophthalmology Visual & Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan.

Survey of ophthalmology

|August 16, 2025

概括

针对新血管与年龄相关的黄斑变性 (nvAMD) 的抗血管内皮生长因子 (VEGF) 注射可以导致黄斑孔 (MH) 形成. 关键的危险因素包括色素上皮质脱落和玻璃瘤引,需要临床意识.

科学领域:

眼科医生眼科眼科
视网膜疾病视网膜疾病
医疗治疗医疗治疗

背景情况:

抗血管内皮生长因子 (VEGF) 注射是新血管与年龄相关的黄斑变性 (nvAMD) 的首要治疗方法.
斑点孔 (MH) 形成是与抗VEGF疗法相关的潜在并发症.
了解风险因素对于患者的安全和治疗疗效至关重要.

研究的目的:

审查和综合现有的文献在 nvAMD.患者的抗VEGF注射后黄斑孔的形成.
确定与MH发展相关的人口和临床特征.
突出可能增加MH形成风险的诱导因素.

主要方法:

在PubMed,Embase和谷歌学者中进行了全面的文献搜索.
包括报告MH形成后抗VEGF注射为nVAMD的研究.
提取的数据包括患者人口统计数据,眼部发现 (例如,下液,色素上皮质脱落,玻璃眼引力) 和治疗细节.

主要成果:

该审查包括15篇文章,涵盖50只眼睛,患者年龄中位数为76岁,54%的参与者是女性.
在MH形成之前,68%的眼睛中存在视网膜下液体和色素上皮质脱落.
在36%的眼睛中观察到玻璃瘤粘附或引,在MH发育之前平均注射3次 (中位诊断时间:60天).

结论:

临床医生必须保持警,对于接受针对nVAMD的抗VEGF治疗的患者斑孔形成的风险.
诸如色素上皮质脱落,玻璃引力和显著的内/下网膜液等诱导因素需要仔细考虑.
需要进一步的研究来阐明潜在的机制,并制定针对抗VEGF相关的黄斑孔的预防策略.

关键词:

抗VEGF注射剂的使用方法黄斑孔是一个巨大的洞.神经血管与年龄相关的黄斑变性.内流体内流体颜料上皮质脱落皮质脱落下腺体液体的使用情况玻璃眼的引力

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