在患有间歇性肺部疾病的成年人中进行的药物II/III期随机对照试验的地理分布
Mingkun Guan1, Emma Marshall2, Sadhana Sughesh3
1Department of General Medicine, Austin Health, Heidelberg, Victoria, Australia.
Chest
|August 16, 2025
概括
对间歇性肺病 (ILD) 的药物试验集中在北美和欧洲,显示出地理差异. 需要努力改善ILD随机对照试验 (RCT) 的全球代表性,以便更好地采用治疗.
科学领域:
- 肺病学和临床试验研究研究
- 临床研究中的全球健康公平.
背景情况:
- 药物随机对照试验 (RCT) 对于推进间歇性肺病 (ILD) 治疗至关重要.
- 全球分布和影响ILDRC的因素需要评估.
研究的目的:
- 评估对ILD的制药RCT的全球分布.
- 调查ILD RCT活动与特定国家的医疗保健质量,社会人口状况和城市人口之间的关联.
主要方法:
- 在clinicaltrials.gov上搜索了II期和III期平行组药物ILDRCT (从开始到2024年2月).
- 提取了试验细节和招聘网站.
- 与国家特定的ILD患病率,医疗保健获取和质量指数 (HAQ),社会人口指数和城市人口百分比相关的RCT数据.
主要成果:
- 已确定168个ILD实验室实验室,其中40%自2020年以来开始;北美和欧洲领导参与.
- 在亚洲和南美洲观察到两十年来ILD RCT活动的增加,最近在特定国家出现下降.
- 参与RCT与HAQ指数和城市人口百分比呈正相关性,特别是在III期试验中.
结论:
- ILD RCT活动表现出显著的地理差异,主要集中在北美和欧洲.
- 尽管全球参与度增加,但RCT研究结果的代表性需要提高.
- 考虑到日益增长的疾病负担,促进更广泛地将ILD RCT发现纳入临床护理是必不可少的.
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