运动和器官-大脑轴:通过新出现的运动来调节神经系统疾病
Yan Dai1, Xiaoke Dou1, Bingqing Nie1
1Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China.
运动通过激活"多器官-大脑轴"有益于大脑健康. 这一途径涉及与大脑沟通的外周器官,在大脑疾病期间改善其功能和平衡.
科学领域:
- 神经科学是一个神经科学.
- 运动生理学 运动生理学
- 系统生物学 系统生物学
背景情况:
- 关于运动和大脑疾病的传统研究侧重于直接的神经效应.
- 周围器官对大脑健康和疾病的贡献往往被忽视.
研究的目的:
- 介绍了新的"多器官-大脑轴"概念.
- 探索外周器官如何调解运动的神经保护作用.
- 将外围适应整合到理解大脑平衡中.
主要方法:
- 审查有关运动,外周器官和大脑功能的现有文献.
- "多器官-大脑轴"的概念框架开发.
- 对参与器官间通信的信号分子和代谢物的分析.
主要成果:
- 周围器官 (骨肌肉,心脏,肝脏,脂肪组织,) 在疾病期间显著影响大脑功能.
- 运动会诱导与大脑沟通的外周器官的适应性反应.
- 这些适应包括肌分泌,基调节,心脏释放和增强肝脏排毒.
结论:
- 运动通过直接的神经通路和"多器官-大脑轴"进行神经保护.
- 周围器官的适应改善了突触可塑性,调节了微质细胞,并优化了大脑的新陈代谢.
- "多器官-大脑轴"为理解和治疗大脑疾病提供了一个新的框架.
更多相关视频
11:54Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
Published on: May 8, 2021
08:52Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
Published on: January 10, 2018
相关概念视频
Neural Regulation
Disorders of the Nervous Tissue
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Enteric Nervous System: Regulation of GI Motor Activity
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
Parkinson's Disease: Overview
Neural Regulation of Blood Pressure
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Neurotransmitters
