婴儿早期每周补充维生素D作为预防维生素D不足的潜在策略:一项两中心的回顾性研究
Kaori Hara-Isono1, Kazumi Morisawa2, Mariko Hida2
1Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; Department of Molecular Endocrinology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.
Pediatrics and neonatology
|August 16, 2025
概括
新生儿每周补充维生素D (VD) 和维生素K (VK) 有效地预防1个月大VD不足. 这种联合疗法是安全的,可以为缺乏VD不足预防策略的地区提供指导方针.
科学领域:
- 儿科 儿科 儿科
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 对于预防维生素D (VD) 缺乏,全球有指导方针,但日本缺乏全国性的建议.
- 在日本,与维生素K (VK) 缺乏相关的出血指南建议每周补充维生素K.
- 该研究调查了每周VD和VK补充剂在预防新生儿VD缺陷方面的有效性.
研究的目的:
- 为了确定婴儿早期每周服用VD和VK补充剂是否能在1个月大时预防VD不足.
- 为了比较补充和不补充的婴儿之间的血清25-基维生素D (25(OH) D) 水平.
- 为了提供证据,制定VD缺陷预防指南.
主要方法:
- 在555名1个月大的婴儿 (2017-2023) 中,对血清25(OH) D水平的回顾性分析.
- 婴儿分为控制 (没有补充),每周 (1000 IU/周) 和每天 (240 IU/天) VD 组;所有接受每周VK.
- 多变量逻辑回归调整为配方摄入量和BMI评估的VD不足的预防.
主要成果:
- 与对照组相比,每周和每天VD组的血清25(OH) D水平显著更高.
- 静脉病缺率为89.4% (对照组),20.0% (每周),25.6% (每天).
- 每周和每天VD补充剂显著降低了VD不足的几率 (OR分别为0.038和0.036) 没有VD过量.
结论:
- 联合每周VD和VK补充剂有效地预防1个月大婴儿的VD缺陷.
- 该疗法是安全的,没有观察到过度静脉疾病的病例.
- 这些发现支持制定全国范围的VD缺陷预防指南,特别是在没有现有建议的地区.
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