对局部发达食道状细胞癌的新辅助化学放射治疗,化学疗法和化学免疫疗法的比较研究
Likun Liu1, Junhong Liu2, Yu Rong2
1Department of Radiation Oncology, Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijizhuang, China.
BMC cancer
|August 16, 2025
概括
化学免疫疗法 (NCIT) 与化学辐射疗法 (NCRT) 或化学疗法 (NCT) 相比,显著改善局部晚期食道状细胞癌 (LAESCC) 的存活率. 辅助疗法进一步提高LAESCC患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 局部发达的食道状细胞癌 (LAESCC) 提出了治疗挑战.
- 将新辅助化学放射治疗 (NCRT),化疗 (NCT) 和化疗免疫治疗 (NCIT) 进行比较对于优化患者的治疗结果至关重要.
- 总生存率 (OS) 是评估LAESCC治疗疗效的一个关键指标.
研究的目的:
- 为了比较新辅助化学放射治疗 (NCRT),化疗 (NCT) 和化学免疫治疗 (NCIT) 在LAESCC患者的疗效.
- 评估和比较三种治疗方式的整体生存率 (OS).
- 评估辅助疗法对LAESCC的生存结果的影响.
主要方法:
- 在2016-2022年期间接受治疗的625名LAESCC患者的回顾性分析.
- 应用治疗权重的逆概率 (IPTW) 进行平衡组比较.
- 使用奇平方测试,费舍尔精确测试和多变量考克斯生存分析进行预后评估.
主要成果:
- 在IPTW调整后,化学免疫疗法 (NCIT) 与NCRT (60.4%) 和NCT (62.5%) 相比,显示出更高的4年OS率 (91.4%).
- IPTW成功地减轻了治疗组之间的基线特征差异.
- 辅助疗法对治疗臂的生存结果产生了积极影响.
结论:
- 新辅助化疗免疫疗法 (NCIT) 为LAESCC患者提供了潜在的生存益处,而不是NCRT和NCT.
- 将NCIT与辅助化疗免疫疗法 (ACIT) 结合起来,可以进一步提高生存率.
- 免疫疗法作为LAESCC多模式治疗的组成部分具有前景,值得进行未来的临床试验.
更多相关视频
06:11Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
9.9K
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.6K
相关概念视频
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
322
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
322
Cancer Therapies
7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
259
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
259
