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新辅助化学免疫疗法与新辅助化学放射疗法在患有边缘切除的食道状细胞癌的患者中

Jun-Peng Lin^1,2,3, Feng-Nian Zhuang^1,2,3, Wei-Jie Chen^1,2,3

¹Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, No. 420 Fuma Road, Fuzhou, 350001, Fujian Province, China.

Journal of translational medicine

|August 16, 2025

概括

新辅助化学疗法与免疫疗法 (NACI) 结合显示了与新辅助化学辐射疗法 (NCRT) 相似的生存结果,用于边缘切除的食道状细胞癌. NACI与较少的严重术后并发症有关,这表明它是一种安全有效的选择.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
胃肠道瘤学胃肠道瘤学

背景情况:

对边缘切除性食道状细胞癌 (ESCC) 的最佳治疗方法进行了辩论.
新辅助化学疗法与免疫疗法 (NACI) 和新辅助化学放射疗法 (NCRT) 结合是潜在的策略.

研究的目的:

在cT3br ESCC患者中比较NACI与NCRT的术后结果和预后.
评估NACI作为边界切除ESCC治疗的安全性和有效性.

主要方法:

对接受NACI或NCRT并随后进行手术的cT3brESCC患者进行回顾性队列研究 (2016年1月至2022年12月).
倾向性得分匹配 (PSM) 来控制混因素.
卡普兰-梅尔对生存结果的分析.

主要成果:

NACI和NCRT显示了可比的R0切除和病理完整响应 (pCR) 率.
与NCRT相比,NACI的重大病理反应 (MPR) 率明显较低.
NCRT与患重症术后并发症的风险更高有关.
生存结果 (总体存活率,无病存活率) 和复发模式在各组之间相似.

结论:

经过手术后的NACI是边界切除ESCC的安全有效治疗方法.
NACI提供与NCRT相比的生存益处,并发症率较低.

关键词:

边界切除的食道状细胞癌.新辅助性化疗或放射治疗.新辅助免疫疗法新辅助免疫疗法经期操作性结果.幸存的生存方式

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