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评估新生儿带血清代谢与青少年心脏代谢风险因素相关的评估
Elvira S Fleury1, George D Papandonatos2, Katherine E Manz3
1Department of Epidemiology, Brown University, Providence, RI, US.
Pediatric research
|August 16, 2025
概括
胎儿暴露于某些代谢途径可能会影响青少年心脏代谢风险. 发现的新生儿代谢特征与不同的青少年风险因素群体有联系,这表明这些疾病的起源在早期.
科学领域:
- 代谢学 代谢学 代谢学
- 健康和疾病的发育起源 (DOHaD)
- 心脏代谢疾病研究研究
背景情况:
- 心脏代谢性疾病 (CMD) 的危险因素可能起源于胎儿发育.
- 连接妊娠条件与CMD风险的生物学途径尚未完全理解.
研究的目的:
- 调查新生儿代谢特征与青少年CMD风险因素之间的关联.
- 确定潜在的生物学途径,将早期暴露与CMD发展联系起来.
主要方法:
- 通过液态染色学高分辨率质谱分析了来自145个母婴二的14384个带血清代谢特征.
- 在12岁时测量了青少年CMD风险因素 (内脏脂肪,脂质,葡萄糖,胰岛素,血压).
- 使用稀疏的部分最小平方回归 (sPLS-R) 来建模新生儿代谢特征与青少年CMD风险因素之间的关联.
主要成果:
- 确定了两组与新生儿代谢概况相关的青少年CMD风险因素.
- 第一组包括内脏脂肪,甘油三,高密度胆固醇,胰岛素和瘦素;第二组包括葡萄糖和静脉血压.
- 178个新生儿的代谢特征与这些风险因素组有关,这些新生儿的代谢特征与31种途径有关,包括短链脂肪酸,维生素和氨基酸代谢,以及糖解和葡萄糖生成.
结论:
- 发现了31种生物学途径,可能调解胎儿环境暴露与青少年CMD风险之间的联系.
- 研究结果表明,基于新生儿代谢概况,有明显的早期心脏代谢轨迹和青少年亚表型.
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