在口腔瘤中评估炎症生物标志物
Aykut Ikinciogullari1, Burak Hazir1, Erdem Aggunlu1
1Department of Otorhinolaryngology Head and Neck Surgery, Ankara Bilkent City Hospital, Ankara, Turkey.
概括
像中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 这样的炎症生物标志物在诊断状瘤,特别是小瘤和高度恶性瘤方面表现有前途,有助于差异诊断.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 唾液腺瘤,包括状腺瘤,由于它们的异质性,造成诊断挑战.
- 炎症生物标志物正在被研究,因为它们有可能提高腺瘤的诊断准确性.
- 区分良性瘤和恶性瘤对于适当的患者管理至关重要.
研究的目的:
- 评估中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR),全身免疫炎症指数 (SII) 和全身炎症反应指数 (SIRI) 在腺瘤差异诊断中的实用性.
- 为了比较这些良性和恶性瘤及其亚型之间的炎症生物标志物.
主要方法:
- 对206名在2019年至2023年期间接受切除术的患者进行了回顾性分析.
- 基于组织病理学诊断 (良性与恶性) 和特定瘤亚型的NLR,PLR,SII和SIRI的计算和比较.
- 统计分析以确定生物标志物水平的显著差异.
主要成果:
- 在整体良性和恶性乳头瘤组之间没有发现NLR,PLR,SII或SIRI的显著差异.
- 血小板与淋巴细胞比率 (PLR) 在高等级,低等级和良性瘤组之间显示出统计学上显著的差异 (P=0.05).
- 与多形腺瘤相比,小瘤的PLR显著较低,SIRI较高 (分别P=0.02和P<0.001).
结论:
- 炎症生物标志物,特别是PLR和SIRI,可能有助于诊断特定的状腺瘤,如小瘤和高级恶性瘤.
- 这些可访问和具有成本效益的标记物需要进一步研究,以便在状腺瘤诊断中得到临床应用.
- 需要进一步的研究来确定这些生物标志物的最终准确性和在临床实践中的最佳使用.
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