在一个胎盘营养中,是否存在维特洛基因的保存?
Silvia Fernanda Toloza-Esparza1, Sergio Marchant2, Nathaly Hernández-Díaz1,3,4
1Laboratorio de Biología Reproductiva de Vertebrados, Grupo de Estudios en Biodiversidad, Universidad Industrial de Santander, Bucaramanga, Colombia.
概括
这项研究在胎盘Marisora sp.中没有发现维原蛋白 (VTGs),这表明这些蛋白质在 advanced 胎盘发育的爬行动物中会丢失. 这一发现突显了哺乳动物与胚胎营养供应的融合进化.
科学领域:
- 进化生物学 进化生物学
- 生殖生物学 生殖生物学
- 分子生物学分子生物学
背景情况:
- 脊椎动物胚胎的营养供应非常不同,从黄体依赖到胎盘营养.
- 维特洛因素 (VTGs) 对于产卵物种的蛋黄形成至关重要.
- 欧特利亚哺乳动物随着母体化的进化而失去VTG,依赖于胎盘营养.
研究的目的:
- 为了调查VTG在Marisora sp.中的存在,这是一种具有高度复杂的胎盘和微小卵的爬行动物.
- 了解爬行动物中必需的胎盘受精生物的营养转移的分子基础.
- 在没有VTG的情况下,探索潜在的替代脂质运输机制.
主要方法:
- 来自Marisora sp.的肝脏和卵巢组织的RNA测序. 在previtellogenesis和vitellogenesis阶段进行.
- 生物信息分析用于识别基因注释,特别用于VTG.
- 识别和分析相关的脂质运输蛋白,如阿波利波蛋白B (ApoB) 和微体三糖转移蛋白 (MTP).
主要成果:
- 在Marisora sp.中没有发现VTG基因注释. 转录基因组.转录基因组.转录基因组.
- 鉴定了阿波利波蛋白B (ApoB) 和微体三糖转移蛋白 (MTP).
- 没有VTG与Marisora sp.的胎盘养策略和微小卵子相关.
结论:
- 在Marisora sp. 的VTGs的损失. 对于理解爬行动物胎盘变的演变来说,这是一个重要的发现.
- 这种进化轨迹显示了与哺乳动物的融合,而在发达母体缩的物种中,VTGs也缺席.
- 需要进一步的基因组和蛋白质组研究来阐明ApoB,MTP和其他脂质载体在Marisora sp.中的精确作用. 生殖. 生殖. 生殖. 生殖.
相关概念视频
01:15Transcytosis of IgG
2.9K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.9K
02:27Background and Environment Affect Phenotype
6.7K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.7K