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Updated: Jun 20, 2026

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
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通过自愿食小鼠对腹性贝类毒素的急性毒性评估

Luis Rodríguez-Santos1, M Carmen Louzao1, Celia Costas1

  • 1Departamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, Spain.

Ecotoxicology and environmental safety
|August 17, 2025
PubMed
概括

腹性贝类毒素 (DST) 在贝类中积累,对消费者构成风险. 这项研究发现,酸 (OA) 和dinofysistoxin-1 (DTX1) 在小鼠中引起的胃肠道问题比通过自愿养的dinofysistoxin-2 (DTX2) 更严重.

关键词:
腹性贝类中毒 (DSP). 腹性贝类中毒. 奥卡迪酸. 没有. 口服中毒性. 口服中毒性. 自发性养是一种自发性养.

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...